SCHEMBL8092966

SCHEMBL8092966

COc1ccc(CCCCC(=O)N2CCC(c3ccccc3)CC2)cc1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.64
RAB9A P51151 2/20 0.64
LMNA P02545 2/20 0.64
HSD11B1 P28845 1/20 0.56
SIGMAR1 Q99720 1/20 0.54
KDM4E B2RXH2 1/20 0.53
ORAI1 Q96D31 1/20 0.53
FKBP1A P62942 1/20 0.52
TSHR P16473 1/20 0.52
KMT2A Q03164 1/20 0.52
MAPT P10636 1/20 0.50
S1PR1 P21453 1/20 0.49
NPC1 O15118 1/20 0.49
TRPC3 Q13507 1/20 0.48
TRPC6 Q9Y210 1/20 0.48
HPGD P15428 1/20 0.48
HIF1A Q16665 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8091251 0.88 SIGMAR1 (0.54) ALDH1A1RAB9ALMNAHSD11B1SIGMAR1
SCHEMBL8092824 0.88 SIGMAR1 (0.59) ALDH1A1RAB9ALMNASIGMAR1TSHR
SCHEMBL8091568 0.85 MEN1 (0.54) ALDH1A1RAB9ALMNAHSD11B1SIGMAR1
SCHEMBL9377300 0.85 DRD2 (0.53) ALDH1A1RAB9ALMNASIGMAR1TSHR
SCHEMBL17117400 0.82 CHRM4 (0.63) ALDH1A1RAB9ALMNAHSD11B1KMT2A
SCHEMBL8097185 0.80 SMN1; SMN2 (0.64) ALDH1A1RAB9ALMNASIGMAR1FKBP1A
SCHEMBL8091036 0.79 SIGMAR1 (0.76) SIGMAR1TSHRKMT2A
SCHEMBL8092580 0.78 GRM5 (0.53) ALDH1A1LMNAKMT2AHPGD
SCHEMBL31329287 0.78 ALDH1A1 (0.66) ALDH1A1SIGMAR1FKBP1AKMT2A
SCHEMBL31329327 0.78 FKBP1A (0.64) ALDH1A1SIGMAR1KDM4EFKBP1ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed