SCHEMBL8091054

SCHEMBL8091054

CC(C)(NCCCc1ccc2ccccc2c1)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.53
CYP1A2 P05177 2/20 0.48
CASR P41180 3/20 0.44
HDAC1 Q13547 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
CYP2A6 P11509 1/20 0.42
MC4R P32245 2/20 0.42
MC5R P33032 2/20 0.42
BCHE P06276 2/20 0.41
MC3R P41968 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8093077 0.91 CASR (0.49) SIGMAR1CYP1A2CASRCYP2A6MC4R
SCHEMBL8096835 0.89 SIGMAR1 (0.46) SIGMAR1CYP1A2CASRMC4RMC5R
SCHEMBL8091780 0.82 SIGMAR1 (0.53) SIGMAR1CYP1A2
SCHEMBL8092957 0.78 L3MBTL1 (0.56) SIGMAR1
SCHEMBL9666471 0.76 SIGMAR1 (0.59) SIGMAR1CYP1A2HDAC1HDAC8CYP2A6
SCHEMBL8099093 0.76 SIGMAR1 (0.52) SIGMAR1
SCHEMBL9752778 0.76 MEN1 (0.46) SIGMAR1
SCHEMBL12251060 0.74 CYP1A2 (0.50) SIGMAR1CYP1A2CASRCYP2A6MC4R
SCHEMBL9373302 0.74 SIGMAR1 (0.68) SIGMAR1CYP1A2MC4RMC5RMC3R
SCHEMBL9752836 0.73 DRD2 (0.45) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1991009594-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1991-07-11 WO claimed
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed
WO-1991009594-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1991-07-11 WO disclosed