Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092957 | 0.95 | L3MBTL1 (0.56) | SIGMAR1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL6231282 | 0.89 | ATM (0.52) | SIGMAR1KMT2AMEN1L3MBTL1CYP2D6 | |
| SCHEMBL9752778 | 0.89 | MEN1 (0.46) | SIGMAR1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL8093024 | 0.89 | SIGMAR1 (0.51) | SIGMAR1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL9378564 | 0.89 | SIGMAR1 (0.51) | SIGMAR1KMT2AMEN1POLBCYP3A4 | |
| SCHEMBL8099093 | 0.89 | SIGMAR1 (0.52) | SIGMAR1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL8096264 | 0.89 | SIGMAR1 (0.51) | SIGMAR1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL9752836 | 0.86 | DRD2 (0.45) | SIGMAR1KMT2AMEN1POLB | |
| SCHEMBL9372954 | 0.86 | SIGMAR1 (0.53) | SIGMAR1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL8084194 | 0.85 | SIGMAR1 (0.59) | SIGMAR1KMT2AMEN1POLBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |