Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091234 | 0.85 | ALDH1A1 (0.39) | PIK3CDPIK3CALMNAGAAKMT2A | |
| SCHEMBL8083332 | 0.84 | KIF11 (0.35) | GAAKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL8096884 | 0.82 | KDM4E (0.39) | PIK3CDPIK3CAMTORPIK3CGBLM | |
| SCHEMBL8105037 | 0.81 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8090321 | 0.80 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8089937 | 0.79 | KIF11 (0.39) | MTORKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL8084459 | 0.79 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8093220 | 0.79 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL8091600 | 0.79 | PIK3CA (0.40) | PIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8093437 | 0.78 | PIK3CA (0.48) | PIK3CDPIK3CAPIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |