Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | PEPD | P12955 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083332 | 0.88 | KIF11 (0.35) | KIF11ALDH1A1MEN1MAPTHPGD | |
| SCHEMBL8090988 | 0.87 | MTOR (0.44) | MTORALDH1A1MEN1MAPTHPGD | |
| SCHEMBL8099890 | 0.85 | GHSR (0.39) | ALDH1A1MEN1MAPTHPGDKMT2A | |
| SCHEMBL8091600 | 0.83 | PIK3CA (0.40) | MTOR | |
| SCHEMBL8083982 | 0.83 | PIK3CD (0.34) | MTORALDH1A1MEN1MAPTHPGD | |
| SCHEMBL8091234 | 0.83 | ALDH1A1 (0.39) | ALDH1A1MEN1MAPTHPGDKMT2A | |
| SCHEMBL8096884 | 0.82 | KDM4E (0.39) | MTORALDH1A1MEN1MAPTHPGD | |
| SCHEMBL8095224 | 0.81 | PIK3CD (0.34) | ALDH1A1MEN1MAPTHPGDKMT2A | |
| SCHEMBL8091208 | 0.79 | PIK3CD (0.44) | MTORALDH1A1MEN1MAPTHPGD | |
| SCHEMBL8083616 | 0.79 | ATR (0.42) | KIF11MTORALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |