Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091600 | 0.89 | PIK3CA (0.40) | PIK3CDPIK3CAMTORPIK3CG | |
| SCHEMBL8090988 | 0.83 | MTOR (0.44) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8083982 | 0.83 | PIK3CD (0.34) | KDM4EMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8091068 | 0.83 | PIK3CD (0.42) | KDM4ENPC1GLARAB9ASMN1; SMN2 | |
| SCHEMBL8089937 | 0.82 | KIF11 (0.39) | KDM4ENPC1KDRMEN1ALDH1A1 | |
| SCHEMBL8091208 | 0.82 | PIK3CD (0.44) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8098056 | 0.82 | KDM4E (0.38) | KDM4ENPC1GLARAB9ASMN1; SMN2 | |
| SCHEMBL8095224 | 0.82 | PIK3CD (0.34) | KDM4ERAB9AMEN1ALDH1A1MAPT | |
| SCHEMBL8083977 | 0.81 | FPR2 (0.52) | PIK3CDPIK3CA | |
| SCHEMBL8097652 | 0.81 | PIK3CD (0.38) | KDM4ENPC1GLARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |