Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476353 | 0.91 | TDP1 (0.46) | PTGS1PTGS2CCR2TDP1MAPT | |
| SCHEMBL8525177 | 0.80 | PTGS1 (0.50) | PTGS1PTGS2CCR2TDP1MAPT | |
| SCHEMBL8524014 | 0.80 | PTGS1 (0.46) | PTGS1PTGS2CCR2TDP1MAPT | |
| SCHEMBL8092078 | 0.80 | PTGS1 (0.48) | PTGS1PTGS2CCR2TDP1MAPT | |
| SCHEMBL8099545 | 0.79 | CCR2 (0.56) | PTGS1PTGS2CCR2MAPTPTGDR | |
| SCHEMBL8476355 | 0.77 | PTGS1 (0.48) | PTGS1PTGS2CCR2TDP1MAPT | |
| SCHEMBL8481365 | 0.72 | PTGS1 (0.53) | PTGS1PTGS2CCR2MAPTSMN1; SMN2 | |
| SCHEMBL27866133 | 0.71 | PTGDR2 (0.48) | PTGS1PTGS2POLBPTGDR2LMNA | |
| SCHEMBL8101589 | 0.70 | PTGS2 (0.61) | PTGS1PTGS2CCR2MAPTLMNA | |
| SCHEMBL9657574 | 0.69 | PTGS1 (0.60) | PTGS1PTGS2CCR2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848703-B1 | DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLO-OXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2000-09-27 | — | — | EP | disclosed |