SCHEMBL8092214

SCHEMBL8092214

O=C(O)c1ccc(CCO)c([N+](=O)[O-])c1

nearest known ligand 0.64

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CASP6 P55212 1/20 0.64
TSHR P16473 2/20 0.58
LMNA P02545 1/20 0.58
HCAR3 P49019 13/20 0.54
APEX1 P27695 1/20 0.54
PDK1 Q15118 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7402680 0.89 CASP6 (0.58) CASP6TSHRLMNAHCAR3APEX1
SCHEMBL7712101 0.89 CASP6 (0.62) CASP6TSHRLMNAHCAR3APEX1
SCHEMBL1483517 0.88 CASP6 (0.66) CASP6TSHRLMNAHCAR3APEX1
SCHEMBL30481076 0.88 CASP6 (0.66) CASP6TSHRLMNAHCAR3APEX1
SCHEMBL2292095 0.87 CASP6 (0.64) CASP6TSHRLMNAHCAR3APEX1
SCHEMBL27411911 0.85 CASP6 (0.62) CASP6TSHRLMNAHCAR3APEX1
SCHEMBL6180268 0.85 HCAR3 (0.64) CASP6TSHRLMNAHCAR3APEX1
SCHEMBL5913447 0.85 CASP6 (0.62) CASP6TSHRLMNAHCAR3APEX1
SCHEMBL6341472 0.85 CASP6 (0.66) CASP6TSHRLMNAHCAR3APEX1
SCHEMBL20757 0.85 PDK1 (0.68) CASP6TSHRLMNAHCAR3APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9359396-B2 Material for supported synthesis and method for growing oligonucleotides or peptides UNIVERSITE CLAUDE BERNARD LYON I (FR) 2016-06-07 US claimed
US-20140135478-A1 MATERIAL FOR SUPPORTED SYNTHESIS AND METHOD FOR GROWING OLIGONUCLEOTIDES OR PEPTIDES UNIVERSITE CLAUDE BERNARD LYON I (FR) 2014-05-15 US claimed
US-12304884-B2 Photo-cleavable surfactants WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2025-05-20 US disclosed
US-20230139837-A1 Photo-Cleavable Surfactants WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2023-05-04 US disclosed
US-11567085-B2 Photo-cleavable surfactants WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2023-01-31 US disclosed
US-20210253519-A1 Photo-Cleavable Surfactants WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2021-08-19 US disclosed
US-9359396-B2 Material for supported synthesis and method for growing oligonucleotides or peptides UNIVERSITE CLAUDE BERNARD LYON I (FR) 2016-06-07 US disclosed
US-20140135478-A1 MATERIAL FOR SUPPORTED SYNTHESIS AND METHOD FOR GROWING OLIGONUCLEOTIDES OR PEPTIDES UNIVERSITE CLAUDE BERNARD LYON I (FR) 2014-05-15 US disclosed
US-6046306-A SOLID PHASE SYNTHESIS OF PEPTIDE NUCLEIC ACIDS ALLOWING OLIGOMER TO BE CLEAVED OFF FROM THE SOLID SUPPORT UNDER THE ALKALINE CONDITIONS CONVENTIONALLY USED FOR OLIGONUCLEOTIDES HOECHST AKTIENGESELLSCHAFT (DE) 2000-04-04 US disclosed
EP-0672700-B1 PNA-synthesis using an aminoprotecting group which is labile against weak acids HOECHST AG (DE) 1999-06-02 EP disclosed
CN-1215404-A Non-dendritic backbone piptide carrier PEPRESEACH A S (DK) 1999-04-28 CN disclosed
EP-0896582-A1 NON-DENDRITIC BACKBONE PEPTIDE CARRIER Pepresearch A/S (DK) 1999-02-17 EP disclosed
WO-1997038011-A1 NON-DENDRITIC BACKBONE PEPTIDE CARRIER PEPRESEARCH A/S (DK) 1997-10-16 WO disclosed
US-5601992-A DETECTING INTERACTION BETWEEN PEPTIDE AND TARGET BY PLACING TARGET INTO CONTAINER, OVERLAYING WITH SUBSTRATE, APPLYING BEADS TO SUBSTRATE, EACH BEAD HAVING ASSOCIATED THEREWITH COPIES OF A SINGLE PEPTIDE, ALLOWING DIFFUSION, REACTION BUNSEN RUSH LABORATORIES, INC. (US) 1997-02-11 US disclosed
EP-0672700-A1 PNA-synthesis using an aminoprotecting group which is labile against weak acids HOECHST AKTIENGESELLSCHAFT (DE) 1995-09-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12304884-B2 Photo-cleavable surfactants PTMS, PRSS1, SRMS CASP6 584/4885TSHR 2734/4885LMNA 1320/4885
US-11567085-B2 Photo-cleavable surfactants PTMS, PRSS1, SRMS CASP6 584/4885TSHR 2734/4885LMNA 1320/4885
US-20230139837-A1 Photo-Cleavable Surfactants PTMS, PRSS1, SRMS CASP6 584/4885TSHR 2734/4885LMNA 1320/4885
US-20210253519-A1 Photo-Cleavable Surfactants PTMS, PRSS1, TMPRSS4 CASP6 546/4885TSHR 2036/4885LMNA 1173/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.