Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.30 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8097779 | 1.00 | ACHE (0.39) | ACHEADRA2AMAOAMAOBPREP | |
| Fumaric Acid SCHEMBL8085007 | 0.90 | ADRA2A (0.46) | ADRA2ALMNABLMHTR1AHTR2A | |
| Fumaric Acid SCHEMBL8091870 | 0.90 | ADRA2A (0.46) | ADRA2ALMNABLMHTR1AHTR2A | |
| Fumaric Acid SCHEMBL8092403 | 0.90 | ADRA2A (0.46) | ADRA2ALMNABLMHTR1AHTR2A | |
| Fumaric Acid SCHEMBL8091878 | 0.90 | ADRA2A (0.46) | ADRA2ALMNABLMHTR1AHTR2A | |
| Fumaric Acid SCHEMBL8085005 | 0.90 | ADRA2A (0.46) | ADRA2ALMNABLMHTR1AHTR2A | |
| Fumaric Acid SCHEMBL8092398 | 0.90 | ADRA2A (0.46) | ADRA2ALMNABLMHTR1AHTR2A | |
| SCHEMBL6955357 | 0.89 | ACHE (0.47) | ACHEADRA2AHTR1AHTR2AHTR7 | |
| SCHEMBL6949362 | 0.77 | ADRA2A (0.56) | ADRA2AHTR1AHTR2AHTR7DRD3 | |
| SCHEMBL6949759 | 0.77 | ADRA2A (0.56) | ADRA2AHTR1AHTR2AHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183907-C | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | SERVIER LAB (FR) | 2005-01-12 | — | — | CN | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |