Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098261 | 0.83 | MTOR (0.43) | MEN1KMT2AKDM4EMAPTPIK3CA | |
| SCHEMBL8092270 | 0.81 | NPC1 (0.43) | NPC1RAB9AFLT3SMN1; SMN2ADORA3 | |
| SCHEMBL8095600 | 0.81 | CA12 (0.39) | MEN1KMT2AKDM4ELIMK1MAPT | |
| SCHEMBL8099638 | 0.80 | FLT3 (0.43) | NPC1RAB9AFLT3SMN1; SMN2ADORA3 | |
| SCHEMBL8089827 | 0.80 | PIK3CD (0.37) | FPR2MAPTPIK3CAMTORKDR | |
| SCHEMBL8083714 | 0.79 | EPHX1 (0.45) | NPC1RAB9AFLT3SMN1; SMN2MEN1 | |
| SCHEMBL8090594 | 0.79 | PIK3CD (0.40) | RAB9AMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL8103978 | 0.79 | ABL1 (0.37) | — | |
| SCHEMBL8092884 | 0.78 | KDR (0.41) | LMNAKITPDGFRAPIK3CAKDR | |
| SCHEMBL8083976 | 0.78 | NPC1 (0.52) | NPC1RAB9AFLT3SMN1; SMN2ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |