Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.36 |
| ▸ | GCK | P35557 | 3/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099234 | 0.89 | KCNH2 (0.35) | ABL1APP | |
| SCHEMBL8098261 | 0.86 | MTOR (0.43) | — | |
| SCHEMBL8092878 | 0.79 | NPC1 (0.46) | — | |
| SCHEMBL8092946 | 0.76 | ABL1 (0.41) | ABL1 | |
| SCHEMBL8095600 | 0.76 | CA12 (0.39) | MAP4K1 | |
| SCHEMBL8090594 | 0.74 | PIK3CD (0.40) | — | |
| SCHEMBL8092884 | 0.73 | KDR (0.41) | — | |
| SCHEMBL8089827 | 0.73 | PIK3CD (0.37) | — | |
| SCHEMBL8213772 | 0.72 | PIK3CD (0.38) | ABL1MAP4K1 | |
| SCHEMBL8083714 | 0.72 | EPHX1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |