Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 4/20 | 0.32 |
| ▸ | CNR2 | P34972 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5782733 | 0.84 | MAPT (0.40) | NPC1RAB9AMAPTPOLBLMNA | |
| SCHEMBL8089555 | 0.78 | NPC1 (0.38) | NPC1RAB9AMAPTPOLBSMN1; SMN2 | |
| SCHEMBL8089505 | 0.76 | CA12 (0.38) | NPC1RAB9AMAPTLMNAMAPK1 | |
| SCHEMBL6188780 | 0.76 | CA12 (0.41) | NPC1RAB9AMAPTCYP2C9LMNA | |
| SCHEMBL7454339 | 0.76 | CA12 (0.38) | NPC1RAB9APOLBLMNASMN1; SMN2 | |
| SCHEMBL8081799 | 0.76 | GABRA1 (0.39) | LMNAMAOBCA12CA1CA2 | |
| SCHEMBL1274782 | 0.76 | CA1 (0.46) | NPC1RAB9APOLBLMNAMAPK1 | |
| SCHEMBL28621595 | 0.74 | ALDH1A1 (0.38) | NPC1RAB9AMAPTCYP2C9LMNA | |
| SCHEMBL2885322 | 0.73 | CA1 (0.50) | MAPTLMNAMAPK1SMN1; SMN2CA12 | |
| SCHEMBL10562502 | 0.72 | CYP1A2 (0.43) | CA12CA1CA2CA4CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051394-A1 | POTASSIUM CHANNEL INHIBITORS | Icagen, Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037607-A1 | POTASSIUM CHANNEL INHIBITORS | ICAGEN, INC. (US) | 1999-07-29 | — | — | WO | disclosed |