Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554234 | 0.89 | MAPT (0.56) | XDHALDH1A1TP53MAPTRAB9A | |
| SCHEMBL7209149 | 0.83 | ALDH1A1 (0.59) | XDHALDH1A1TP53MAPTRAB9A | |
| SCHEMBL8559038 | 0.80 | ALDH1A1 (0.53) | XDHALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL10465972 | 0.76 | MAPKAPK2 (0.47) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL10723745 | 0.74 | XDH (0.47) | XDHALDH1A1TP53MAPTKDM4E | |
| SCHEMBL10723749 | 0.74 | XDH (0.50) | XDHALDH1A1TP53MAPTSMN1; SMN2 | |
| SCHEMBL3762307 | 0.73 | MAPT (0.76) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL31325519 | 0.72 | L3MBTL1 (0.53) | XDHALDH1A1TP53MAPTRAB9A | |
| SCHEMBL8559047 | 0.72 | RIPK1 (0.62) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3764806 | 0.71 | MAPT (0.78) | ALDH1A1MAPTRAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |