Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1275787 | 0.82 | DYRK1A (0.41) | NPSR1 | |
| SCHEMBL822036 | 0.80 | MAPT (0.56) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL6826748 | 0.80 | SLC6A2 (0.40) | KDM4E | |
| SCHEMBL809535 | 0.77 | KIF11 (0.41) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL814203 | 0.75 | SLC6A2 (0.49) | CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL1722733 | 0.75 | GAA (0.51) | HPGDLMNAGAACYP3A4MAPT | |
| SCHEMBL22728965 | 0.73 | PRCP (0.58) | HPGDGAAHTTCYP3A4MAPT | |
| SCHEMBL10557174 | 0.73 | KDM4E (0.57) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL16340316 | 0.73 | PRCP (0.51) | ALDH1A1HPGDKDM4EHSD17B10LMNA | |
| SCHEMBL808897 | 0.70 | GID4 (0.55) | ALDH1A1HPGDKDM4EHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1955992-B1 | Process for the preparation of 1-aryl-3, 4-dihydro-1h-napthalene-2-one | TOKUYAMA CORP (JP) | 2011-11-23 | — | — | EP | disclosed |
| EP-1955992-B1 | Process for the preparation of 1-aryl-3, 4-dihydro-1h-napthalene-2-one | TOKUYAMA CORP (JP) | 2011-11-23 | — | — | EP | disclosed |
| US-7728154-B2 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2010-06-01 | — | — | US | disclosed |
| US-7728154-B2 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2010-06-01 | — | — | US | disclosed |
| US-7728154-B2 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2010-06-01 | — | — | US | disclosed |
| US-20080200697-A1 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-21 | — | — | US | disclosed |
| US-20080200697-A1 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-21 | — | — | US | disclosed |
| US-20080200697-A1 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-21 | — | — | US | disclosed |
| EP-1955992-A2 | Process for the preparation of 1-aryl-3, 4-dihydro-1h-napthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-13 | — | — | EP | disclosed |
| EP-1955992-A2 | Process for the preparation of 1-aryl-3, 4-dihydro-1h-napthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200697-A1 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | SULT1E1, CYP2S1, SULT1A1 | SCN9A 508/4885ALDH1A1 874/4885HPGD 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.