Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13343323 | 0.82 | ALDH1A1 (0.53) | KDM4EALDH1A1HPGDCASP1HSD17B10 | |
| SCHEMBL27861333 | 0.78 | LMNA (0.36) | HPGDCYP3A4LMNACYP1A2 | |
| SCHEMBL809380 | 0.77 | SCN9A (0.50) | ALOX5CYP2D6KDM4EALDH1A1GLA | |
| SCHEMBL13343320 | 0.76 | MAPT (0.54) | CYP2D6KDM4EALDH1A1HSD17B10CYP3A4 | |
| SCHEMBL1722733 | 0.74 | GAA (0.51) | HPGDCYP3A4LMNACYP1A2 | |
| SCHEMBL5315718 | 0.73 | CYP1A2 (0.54) | CYP2D6ALDH1A1HSD17B10CYP3A4CYP2C9 | |
| SCHEMBL11714513 | 0.72 | KDM1A (0.61) | — | |
| SCHEMBL6617779 | 0.70 | CYP2D6 (0.43) | CYP2D6KDM4EALDH1A1GLAHPGD | |
| SCHEMBL809758 | 0.70 | CA1 (0.55) | — | |
| SCHEMBL822036 | 0.69 | MAPT (0.56) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1955992-B1 | Process for the preparation of 1-aryl-3, 4-dihydro-1h-napthalene-2-one | TOKUYAMA CORP (JP) | 2011-11-23 | — | — | EP | disclosed |
| US-7728154-B2 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2010-06-01 | — | — | US | disclosed |
| US-7728154-B2 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2010-06-01 | — | — | US | disclosed |
| US-7728154-B2 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2010-06-01 | — | — | US | disclosed |
| US-20080200697-A1 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-21 | — | — | US | disclosed |
| US-20080200697-A1 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-21 | — | — | US | disclosed |
| US-20080200697-A1 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-21 | — | — | US | disclosed |
| EP-1955992-A2 | Process for the preparation of 1-aryl-3, 4-dihydro-1h-napthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-13 | — | — | EP | disclosed |
| EP-1955992-A2 | Process for the preparation of 1-aryl-3, 4-dihydro-1h-napthalene-2-one | TOKUYAMA CORPORATION (JP) | 2008-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200697-A1 | Process for the preparation of 1-aryl-3,4-dihydro-1H-naphthalene-2-one | SULT1E1, CYP2S1, SULT1A1 | KIF11 1494/4885ALOX5 1646/4885CYP2D6 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.