Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.54 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9672111 | 0.91 | MMP2 (0.50) | CYP1A2CYP1A1CYP1B1MMP2MMP12 | |
| SCHEMBL487492 | 0.86 | CYP1A2 (0.58) | CYP1A2MMP2MMP12KDM4ELMNA | |
| SCHEMBL26668449 | 0.85 | MMP2 (0.48) | MMP2MMP12ALDH1A1MMP13MMP3 | |
| SCHEMBL17616892 | 0.84 | MMP2 (0.46) | CYP1A2CYP1A1CYP1B1MMP2MMP12 | |
| SCHEMBL26668399 | 0.84 | MMP2 (0.55) | MMP2MMP12KDM4ELMNAPOLB | |
| SCHEMBL6446069 | 0.83 | MMP2 (0.55) | CYP1A2MMP2MMP12KDM4ELMNA | |
| SCHEMBL2161747 | 0.83 | CYP1A2 (0.50) | CYP1A2CYP1A1CYP1B1MMP2CYP3A4 | |
| SCHEMBL10453876 | 0.83 | MMP3 (0.50) | MMP2MMP12MMP3BCL2L1APP | |
| SCHEMBL11485198 | 0.82 | ALDH1A1 (0.44) | CYP1A2MMP2MMP12KDM4ELMNA | |
| SCHEMBL11557111 | 0.81 | MMP2 (0.43) | CYP1A2CYP1A1CYP1B1MMP2MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117466790-B | Preparation method of alpha-sulfinylated carbonyl compound | 西北师范大学 | 2024-05-28 | — | — | CN | claimed |
| CN-117466790-A | Preparation method of alpha-sulfinylated carbonyl compound | 西北师范大学 | 2024-01-30 | — | — | CN | claimed |
| CN-117466790-B | Preparation method of alpha-sulfinylated carbonyl compound | 西北师范大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-117466790-A | Preparation method of alpha-sulfinylated carbonyl compound | 西北师范大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-110483400-B | Preparation method of pyrazole derivative | 上海应用技术大学 | 2023-04-28 | — | — | CN | disclosed |
| CN-110467514-B | Preparation method of alpha-halogenated unsaturated aldehyde ketone | 上海应用技术大学 | 2023-03-28 | — | — | CN | disclosed |
| CN-110483430-B | Preparation method of isoxazole derivative | 上海应用技术大学 | 2023-02-10 | — | — | CN | disclosed |
| US-10829464-B2 | Benzoheterocyclic alkylamine compounds and use thereof | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2020-11-10 | — | — | US | disclosed |
| US-20190315703-A1 | BENZOHETEROCYCLIC ALKYLAMINE COMPOUNDS AND USE THEREOF | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2019-10-17 | — | — | US | disclosed |
| EP-3546454-A1 | BENZOHETEROCYCLYL ALKYLAMINE COMPOUND AND USE THEREOF | East China University of Science and Technology (CN) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018095287-A1 | BENZOHETEROCYCLYL ALKYLAMINE COMPOUND AND USE THEREOF | 华东理工大学 | 2018-05-31 | — | — | WO | disclosed |
| US-20040063777-A1 | 3-Substituted-3-(substitutedsulfonyl or sulfanyl)pyrrolidine-2,5-diones useful for inhibition of farnesyl-protein transferase | WYETH HOLDINGS CORPORATION | 2004-04-01 | — | — | US | disclosed |
| US-20040063971-A1 | 3-substituted-3-(substitutedsulfonyl or sulfanyl) pyrrolidine-2,5-diones useful for inhibition of farnesyl-protein transferase | WYETH HOLDINGS CORPORATION | 2004-04-01 | — | — | US | disclosed |
| WO-2004007469-A1 | NEW ALKYNYLATED QUINAZOLIN COMPOUNDS AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |
| US-6605628-B1 | Treatment of ras oncogene-dependent tumors; controlling metastasis, suppressing angiogenesis, inducing apoptosis | WYETH HOLDINGS CORPORATION | 2003-08-12 | — | — | US | disclosed |
| US-20030149063-A1 | 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones useful for inhibition of farnesyl-protein transferase | AMERICAN CYANAMID COMPANY | 2003-08-07 | — | — | US | disclosed |
| US-20030144301-A1 | Method of using 5-(arysulfonyl)-, 5-(arylsulfanyl)-and 5-(arylsulfanyl)thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase | AMERICAN CYANAMID COMPANY (US) | 2003-07-31 | — | — | US | disclosed |
| US-20030083364-A1 | 3-Substituted-3-(substitutedsulfonyl or sulfanyl)pyrroldine-2,5-diones useful for inhibition of farnesyl-protein transferase | AMERICAN CYANAMID COMPANY | 2003-05-01 | — | — | US | disclosed |
| WO-2003033478-A1 | ALKYNYLATED FUSED RING PYRIMIDINE COMPOUNDS AS MATRIX METALLOPROTEASE-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003018135-A1 | METHOD OF USING 5-(ARYLSULFONYL)-,5-(ARYLSULFINYL), AND 5-(ARYLSULFANYL)-THIAZOLIDINE-2,4-DIONES FOR INHIBITION OF FARNESYL-PROTEIN TRANSFERASE | WYETH HOLDINGS CORPORATION (US) | 2003-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144301-A1 | Method of using 5-(arysulfonyl)-, 5-(arylsulfanyl)-and 5-(arylsulfanyl)thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase | FNTB, FNTA, TST | CYP1A2 1906/4885CYP1A1 1824/4885CYP1B1 1238/4885 |
| US-20040063777-A1 | 3-Substituted-3-(substitutedsulfonyl or sulfanyl)pyrrolidine-2,5-diones useful for inhibition of farnesyl-protein transferase | FNTA, FNTB, FDPS | CYP1A2 2159/4885CYP1A1 1638/4885CYP1B1 1020/4885 |
| US-20030149063-A1 | 5-(arylsulfonyl)-,5-(arylsulfinyl), and 5-(arylsulfanyl)-thiazolidine-2,4-diones useful for inhibition of farnesyl-protein transferase | FNTB, FNTA, NAT1 | CYP1A2 1353/4885CYP1A1 780/4885CYP1B1 678/4885 |
| US-10829464-B2 | Benzoheterocyclic alkylamine compounds and use thereof | AADAC, AAAS, NISCH | CYP1A2 1004/4885CYP1A1 1450/4885CYP1B1 347/4885 |
| US-20030083364-A1 | 3-Substituted-3-(substitutedsulfonyl or sulfanyl)pyrroldine-2,5-diones useful for inhibition of farnesyl-protein transferase | FNTA, FNTB, FDPS | CYP1A2 1968/4885CYP1A1 1574/4885CYP1B1 691/4885 |
| US-20190315703-A1 | BENZOHETEROCYCLIC ALKYLAMINE COMPOUNDS AND USE THEREOF | AADAC, AAAS, NISCH | CYP1A2 1004/4885CYP1A1 1450/4885CYP1B1 347/4885 |
| US-20040063971-A1 | 3-substituted-3-(substitutedsulfonyl or sulfanyl) pyrrolidine-2,5-diones useful for inhibition of farnesyl-protein transferase | FNTA, FNTB, FDPS | CYP1A2 2159/4885CYP1A1 1638/4885CYP1B1 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.