Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13945424 | 0.84 | HTR1D (0.47) | PDE2AHTR2BNCF1CHRM4JAK2 | |
| SCHEMBL8091569 | 0.79 | CYP3A4 (0.49) | CHRM4ATMALDH1A1 | |
| SCHEMBL8092993 | 0.77 | HTR2B (0.44) | HTR2BCHRM4ATMACHE | |
| SCHEMBL8096499 | 0.77 | GAA (0.53) | NCF1ACHEGAABCHE | |
| SCHEMBL8095852 | 0.73 | CCR3 (0.47) | ATMALDH1A1KDM4EMAPTHTT | |
| SCHEMBL27822767 | 0.72 | DPP4 (0.57) | PDE2AHTR2BCHRM4CHRM2JAK2 | |
| SCHEMBL8103772 | 0.70 | DPP4 (0.43) | ATMCHRM1ACHEALDH1A1KDM4E | |
| SCHEMBL1935654 | 0.70 | ALDH1A1 (0.63) | PDE2AHTR2BNCF1JAK2JAK1 | |
| SCHEMBL29668952 | 0.70 | CHKA (0.62) | PDE2AHTR2BJAK2JAK1JAK3 | |
| SCHEMBL20238481 | 0.70 | CHKA (0.62) | PDE2AHTR2BJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000085-A1 | QUINOLINE AND QUINAZOLINE DERIVATIVES USEFUL AS MODULATORS OF GATED ION CHANNELS | PAINCEPTOR PHARMA CORPORATION (CA) | 2008-12-31 | — | — | WO | disclosed |