Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.51 |
| ▸ | CA2 | P00918 | 4/20 | 0.51 |
| ▸ | CA9 | Q16790 | 4/20 | 0.51 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | FPR1 | P21462 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083324 | 0.98 | FPR2 (0.56) | FPR2MEN1KMT2ARAB9APOLB | |
| SCHEMBL8083304 | 0.84 | ALDH1A1 (0.54) | MEN1KMT2ARAB9APOLBSMN1; SMN2 | |
| SCHEMBL8091318 | 0.84 | TP53 (0.56) | MEN1KMT2ARAB9ASMN1; SMN2CA1 | |
| SCHEMBL8095018 | 0.83 | RAB9A (0.60) | FPR2MEN1KMT2ARAB9APOLB | |
| SCHEMBL8091346 | 0.82 | ALDH1A1 (0.56) | MEN1KMT2ARAB9APOLBSMN1; SMN2 | |
| SCHEMBL8663690 | 0.81 | ACP1 (0.62) | KMT2ARAB9APOLBSMN1; SMN2LMNA | |
| SCHEMBL6463101 | 0.81 | SAE1 (0.51) | MEN1KMT2APOLBSMN1; SMN2LMNA | |
| SCHEMBL8083369 | 0.77 | MEN1 (0.59) | MEN1KMT2ARAB9APOLBSMN1; SMN2 | |
| SCHEMBL8083234 | 0.75 | EPHX1 (0.62) | MEN1KMT2ARAB9APOLBLMNA | |
| SCHEMBL9487965 | 0.75 | CA1 (0.65) | MEN1KMT2ARAB9APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147115-A | SULFONYLUREIDO-4-HALOBENZENE DERIVATIVES; ANTICARCINOGENIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0467621-B1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | LILLY CO ELI (US) | 1994-06-15 | — | — | EP | disclosed |
| US-5216026-A | Administering to the mammal N-1-butanesulfonamide derivatives and salts | ELI LILLY AND COMPANY (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0467621-A1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |