Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095289 | 0.92 | CARM1 (0.36) | TSHRCARM1PRMT6PRMT8CA12 | |
| SCHEMBL10431348 | 0.77 | KEAP1 (0.50) | KEAP1SMN1; SMN2ALDH1A1KDM1A | |
| SCHEMBL8104876 | 0.75 | KEAP1 (0.40) | KEAP1SMN1; SMN2ALDH1A1KDM1A | |
| SCHEMBL4881270 | 0.71 | HRH3 (0.39) | SMN1; SMN2TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL4967445 | 0.67 | HSD17B10 (0.46) | SMN1; SMN2TSHRCA1CA2CA9 | |
| SCHEMBL12937 | 0.64 | ALDH1A1 (0.54) | KEAP1SMN1; SMN2CA12CA1CA2 | |
| SCHEMBL682249 | 0.64 | CA12 (0.46) | KEAP1SMN1; SMN2TSHRCARM1PRMT6 | |
| SCHEMBL9085403 | 0.63 | SLC6A2 (0.38) | KEAP1SMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10409514 | 0.63 | CA12 (0.42) | KEAP1SMN1; SMN2TSHRCA12CA1 | |
| SCHEMBL1685458 | 0.63 | KEAP1 (0.61) | KEAP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | claimed |
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | disclosed |