Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881270 | 0.85 | HRH3 (0.39) | SMN1; SMN2LMNAALDH1A1KDM1AHRH3 | |
| SCHEMBL10431348 | 0.77 | KEAP1 (0.50) | KEAP1SMN1; SMN2HPGDDUSP3GAA | |
| SCHEMBL8095419 | 0.75 | KEAP1 (0.33) | KEAP1SMN1; SMN2ALDH1A1KDM1A | |
| SCHEMBL10409485 | 0.72 | ALDH1A1 (0.54) | KEAP1SMN1; SMN2HPGDDUSP3GAA | |
| SCHEMBL8104864 | 0.71 | TDP1 (0.37) | — | |
| SCHEMBL9375717 | 0.66 | ACE2 (0.37) | KEAP1SMN1; SMN2KDM1AKMT2A | |
| SCHEMBL8095289 | 0.65 | CARM1 (0.36) | ALDH1A1KDM1AHRH3 | |
| SCHEMBL4312012 | 0.65 | HPGD (0.53) | KEAP1SMN1; SMN2HPGDDUSP3GAA | |
| SCHEMBL8104652 | 0.64 | TDP1 (0.41) | — | |
| SCHEMBL1685458 | 0.64 | KEAP1 (0.61) | KEAP1SMN1; SMN2KDM4EALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | disclosed |