Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096140 | 1.00 | GAA (0.50) | GAANPSR1TDP1NAAAMAPT | |
| SCHEMBL8430097 | 0.80 | GAA (0.56) | GAANPSR1TDP1MAPTL3MBTL1 | |
| SCHEMBL8096306 | 0.75 | CTSL (0.57) | GAAMAPTL3MBTL1 | |
| SCHEMBL8096310 | 0.75 | CTSL (0.57) | GAAMAPTL3MBTL1 | |
| SCHEMBL8322566 | 0.75 | RAB9A (0.48) | GAANPSR1TDP1MAPTL3MBTL1 | |
| SCHEMBL28758619 | 0.74 | GAA (0.65) | GAANPSR1TDP1MAPTL3MBTL1 | |
| SCHEMBL2033165 | 0.72 | MAPK1 (0.73) | GAANAAANPC1RAB9AHDAC3 | |
| SCHEMBL8779817 | 0.72 | HDAC1 (0.79) | GAANAAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9491686 | 0.72 | NPC1 (0.75) | GAANPSR1NAAANPC1RAB9A | |
| SCHEMBL6202779 | 0.71 | NPC1 (0.64) | GAATDP1NAAAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034272-A | CARDIOVASCULAR DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-03-07 | — | — | US | claimed |
| WO-1998057929-A1 | ELEVATION OF HDL CHOLESTEROL BY N-[4-[ (AMINOTHIOXOMETHYL) HYDRAZONO] -4-ARYLBUTYL]AMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | claimed |
| US-6034272-A | CARDIOVASCULAR DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-03-07 | — | — | US | disclosed |
| WO-1998057929-A1 | ELEVATION OF HDL CHOLESTEROL BY N-[4-[ (AMINOTHIOXOMETHYL) HYDRAZONO] -4-ARYLBUTYL]AMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |