SCHEMBL8097095

SCHEMBL8097095

O=C1NC(c2cccc(OC(F)(F)C(F)F)c2)SC1Cl

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PIM1 P11309 1/20 0.41
PIM2 Q9P1W9 1/20 0.41
ALDH1A1 P00352 2/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
TSHR P16473 1/20 0.40
CETP P11597 14/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
BRD4 O60885 1/20 0.35
CREBBP Q92793 1/20 0.35
EPHX2 P34913 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8089669 0.90 ALDH1A1 (0.47) PIM1PIM2ALDH1A1MAPTHPGD
SCHEMBL8090577 0.85 PIM1 (0.41) PIM1PIM2ALDH1A1MAPTHPGD
SCHEMBL8097219 0.78 ALDH1A1 (0.45) ALDH1A1MAPTHPGDTSHRLMNA
SCHEMBL8096948 0.77 PBRM1 (0.46) PIM1PIM2ALDH1A1MAPTHPGD
SCHEMBL8103732 0.77 GFER (0.46) PIM1PIM2ALDH1A1MAPTCETP
SCHEMBL8098680 0.76 LMNA (0.38) PIM1PIM2ALDH1A1MAPTHPGD
SCHEMBL8103664 0.74 ALDH1A1 (0.44) PIM1PIM2ALDH1A1MAPTHPGD
SCHEMBL8097655 0.73 ALDH1A1 (0.70) ALDH1A1MAPTHPGDTSHRLMNA
SCHEMBL8089623 0.72 ALDH1A1 (0.49) ALDH1A1MAPTHPGDTSHR
SCHEMBL8099399 0.69 MAPT (0.49) ALDH1A1MAPTHPGDTSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0672038-B1 HERBICIDES ZENECA LTD (GB) 2000-01-19 EP disclosed
US-5856273-A CONTROLLING WEEDS ZENECA LIMITED (GB) 1999-01-05 US disclosed
EP-0672038-A1 HERBICIDES ZENECA LIMITED (GB) 1995-09-20 EP disclosed
WO-1994013652-A1 HERBICIDES ZENECA LIMITED (GB) 1994-06-23 WO disclosed