Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088811 | 0.84 | GPR119 (0.44) | GPR119MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8098303 | 0.82 | CCR5 (0.43) | ALDH1A1KMT2A | |
| SCHEMBL8101308 | 0.80 | KDM4E (0.41) | MEN1ALDH1A1KMT2A | |
| SCHEMBL8534856 | 0.75 | CYP11B1 (0.49) | GPR119MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8097403 | 0.75 | CYP11B1 (0.49) | GPR119MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8097399 | 0.75 | GPR119 (0.43) | GPR119MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL8095339 | 0.74 | GPR119 (0.41) | GPR119ALDH1A1JAK2JAK1CYP11B1 | |
| SCHEMBL8097494 | 0.72 | GPR119 (0.42) | GPR119JAK2JAK1CYP11B1CYP11B2 | |
| SCHEMBL8097497 | 0.72 | GPR119 (0.42) | GPR119JAK2JAK1CYP11B1CYP11B2 | |
| SCHEMBL8096857 | 0.72 | GPR119 (0.42) | GPR119JAK2JAK1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127366-A | ANTICARCINOGENIC OR ANTITUMOR AGENTS | MERCK & CO., INC. (US) | 2000-10-03 | — | — | US | disclosed |