Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8649980 | 0.94 | GABRA2 (0.45) | MAPTMAPK1ATMGABRA2GABRB2 | |
| SCHEMBL8650346 | 0.89 | MAPT (0.39) | MAPTMAPK1ATMGABRA2GABRB2 | |
| SCHEMBL8316817 | 0.85 | SMN1; SMN2 (0.40) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8317672 | 0.82 | SMN1; SMN2 (0.37) | MAPTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8098049 | 0.81 | SMN1; SMN2 (0.35) | GABRA2GABRB2GABRA1GABRG2GABRB3 | |
| SCHEMBL8098249 | 0.81 | CYP1A2 (0.33) | MAPTGABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL8642931 | 0.80 | GABRA2 (0.44) | MAPTGABRA2GABRB2 | |
| SCHEMBL8879965 | 0.80 | MAPT (0.46) | MAPTMAPK1ATMGABRA2GABRB2 | |
| SCHEMBL8646311 | 0.80 | GABRA2 (0.42) | MAPTGABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL8100190 | 0.80 | SMN1; SMN2 (0.33) | MAPK1GABRA2GABRB2GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772615-B1 | IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE POULENC RORER SA (FR) | 1999-09-22 | — | — | EP | disclosed |
| US-5726175-A | MULTISTAGE PROCESS WITH CYCLIZATION AND AMINATION | RHONE-POULENC RORER S.A. (FR) | 1998-03-10 | — | — | US | disclosed |
| WO-1997025326-A1 | 2-SUBSTITUTED 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1997-07-17 | — | — | WO | disclosed |
| EP-0772615-A1 | IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996002544-A1 | IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1996-02-01 | — | — | WO | disclosed |