Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 0.49 |
| ▸ | CTSB | P07858 | 16/20 | 0.49 |
| ▸ | CTSS | P25774 | 15/20 | 0.49 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8110058 | 0.80 | CTSK (0.56) | CTSKCTSBCTSSADAM10ERBB2 | |
| SCHEMBL8110145 | 0.72 | HRH3 (0.50) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8099548 | 0.71 | CTSK (0.68) | CTSKCTSBCTSSADAM10ERBB2 | |
| SCHEMBL8099356 | 0.70 | CTSB (0.47) | CTSKCTSBCTSSADAM10MMP2 | |
| SCHEMBL4878854 | 0.70 | HTR6 (0.55) | CTSBTSHR | |
| SCHEMBL8111374 | 0.69 | CTSB (0.59) | CTSKCTSBCTSSKCNH2 | |
| SCHEMBL8110520 | 0.68 | CTSK (0.64) | CTSKCTSBCTSSADAM10ERBB2 | |
| SCHEMBL8107852 | 0.68 | CTSK (0.75) | CTSKCTSBCTSSCYP3A4CYP2C9 | |
| SCHEMBL8099124 | 0.68 | CTSK (0.75) | CTSKCTSBCTSSCYP3A4CYP2C9 | |
| SCHEMBL8106379 | 0.66 | CTSK (0.76) | CTSKCTSBCTSSKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |