Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | RXRA | P19793 | 12/20 | 0.39 |
| ▸ | RXRB | P28702 | 12/20 | 0.39 |
| ▸ | RXRG | P48443 | 12/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.38 |
| ▸ | RARA | P10276 | 2/20 | 0.37 |
| ▸ | RARB | P10826 | 2/20 | 0.37 |
| ▸ | RARG | P13631 | 2/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102297 | 0.76 | CYP3A4 (0.40) | CYP3A4RXRARXRBRXRGCYP26A1 | |
| SCHEMBL8100977 | 0.76 | CYP3A4 (0.40) | CYP3A4RXRARXRBRXRGCYP26A1 | |
| SCHEMBL8103047 | 0.75 | RXRA (0.47) | RXRARXRBRXRGCYP26A1RARB | |
| SCHEMBL8106425 | 0.73 | RXRA (0.39) | CYP3A4RXRARXRBRXRGCYP26A1 | |
| SCHEMBL8102921 | 0.73 | RXRA (0.51) | CYP3A4RXRARXRBRXRGCYP26A1 | |
| SCHEMBL8093051 | 0.73 | RXRA (0.64) | CYP3A4RXRARXRBRXRGCYP26A1 | |
| SCHEMBL8102605 | 0.70 | RXRA (0.53) | RXRARXRBRXRGCYP26A1RARA | |
| SCHEMBL8102771 | 0.70 | ALDH1A1 (0.51) | CYP3A4RXRARXRBRXRGCYP26A1 | |
| SCHEMBL8556010 | 0.70 | RXRA (0.49) | RXRARXRBRXRGRARARARB | |
| SCHEMBL8839312 | 0.69 | RXRA (0.43) | CYP3A4RXRARXRBRXRGCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661260-B1 | New bi-aromatic compounds derived from amides pharmaceutical compositions and cosmetic compositions containing them and their use | CIRD GALDERMA (FR) | 1997-03-12 | — | — | EP | claimed |
| US-6051243-A | USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-04-18 | — | — | US | disclosed |