Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | RXRA | P19793 | 8/20 | 0.46 |
| ▸ | RXRB | P28702 | 7/20 | 0.46 |
| ▸ | RXRG | P48443 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.43 |
| ▸ | RARB | P10826 | 3/20 | 0.43 |
| ▸ | RARG | P13631 | 3/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106419 | 0.86 | MAPT (0.47) | ALDH1A1MAPTHPGDRXRARXRB | |
| SCHEMBL8093051 | 0.84 | RXRA (0.64) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8102921 | 0.81 | RXRA (0.51) | ALDH1A1RXRARXRBRXRGLMNA | |
| SCHEMBL8839024 | 0.81 | KMT2A (0.56) | ALDH1A1MAPTHPGDRXRARXRB | |
| SCHEMBL8103047 | 0.79 | RXRA (0.47) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL9551719 | 0.77 | RARB (0.54) | ALDH1A1MAPTHPGDRXRARXRB | |
| SCHEMBL8556010 | 0.75 | RXRA (0.49) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8102485 | 0.74 | RXRA (0.64) | ALDH1A1RXRARXRBRXRGKMT2A | |
| SCHEMBL8558866 | 0.74 | RXRA (0.48) | ALDH1A1RXRARXRBRXRGKMT2A | |
| SCHEMBL6144299 | 0.74 | ALDH1A1 (0.45) | ALDH1A1MAPTHPGDRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051243-A | USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-04-18 | — | — | US | disclosed |