Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 17/20 | 0.47 |
| ▸ | RXRB | P28702 | 17/20 | 0.47 |
| ▸ | RXRG | P48443 | 16/20 | 0.47 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | RARB | P10826 | 2/20 | 0.39 |
| ▸ | RARG | P13631 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093051 | 0.87 | RXRA (0.64) | RXRARXRBRXRGCYP26A1RARB | |
| SCHEMBL8102921 | 0.87 | RXRA (0.51) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL8102605 | 0.82 | RXRA (0.53) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL8102771 | 0.79 | ALDH1A1 (0.51) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL8556010 | 0.78 | RXRA (0.49) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL8102297 | 0.77 | CYP3A4 (0.40) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL5080288 | 0.75 | RXRA (0.65) | RXRARXRBRXRGCYP26A1RARB | |
| SCHEMBL8102435 | 0.75 | RXRA (0.61) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL8100718 | 0.75 | CYP3A4 (0.40) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL5084705 | 0.74 | RXRA (0.64) | RXRARXRBRXRGCYP26A1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051243-A | USEFUL IN THE TOPICAL AND SYSTEMIC TREATMENT OF DERMATOLOGICAL CONDITIONS ASSOCIATED WITH A KERATINIZATION DISORDER, DERMATOLOGICAL CONDITIONS (AND THE LIKE) INCLUDING AN INFLAMMATORY AND/OR IMMUNOALLERGIC COMPONENT | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2000-04-18 | — | — | US | disclosed |