Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Perchlorate SCHEMBL8095660 | 0.92 | VDR (0.41) | VDRALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL8100119 | 0.92 | KMT2A (0.38) | VDRALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL2828593 | 0.70 | GAA (0.42) | VDRALDH1A1KMT2AMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL8095270 | 0.68 | GAA (0.37) | VDRALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL29838651 | 0.67 | ALDH1A1 (0.47) | VDRALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL859822 | 0.67 | ALDH1A1 (0.47) | VDRALDH1A1KMT2AMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL8095522 | 0.67 | GAA (0.36) | ALDH1A1KMT2AMAPTKDM4EHPGD | |
| SCHEMBL8087971 | 0.67 | ALDH1A1 (0.44) | VDRALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL8088854 | 0.67 | ALDH1A1 (0.44) | VDRALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL14697334 | 0.67 | ALDH1A1 (0.59) | ALDH1A1KMT2AMAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1061904-A1 | NANOPARTICLES, METHOD FOR PRODUCING NANOPARTICLES AND USE OF THE SAME | Aventis Research & Technologies GmbH & Co KG (DE) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999047130-A1 | NANOPARTICLES, METHOD FOR PRODUCING NANOPARTICLES AND USE OF THE SAME | AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO. KG (DE) | 1999-09-23 | — | — | WO | disclosed |