Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | HTR1A | P08908 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083799 | 0.95 | MAOB (0.52) | MAOBHTR1ADRD2DRD3 | |
| SCHEMBL8092753 | 0.90 | DRD2 (0.49) | MAOBHTR1ADRD2 | |
| SCHEMBL6953084 | 0.83 | MAOB (0.62) | MAOBHTR1A | |
| SCHEMBL6946848 | 0.83 | MAOB (0.71) | MAOBHTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL31491133 | 0.81 | HTR1A (0.48) | MAOBHTR1ACHRM2CHRM4CHRM5 | |
| SCHEMBL30022123 | 0.79 | POLB (0.54) | — | |
| Hydrochloric Acid SCHEMBL31491177 | 0.77 | SIGMAR1 (0.43) | MAOBHTR1ACHRM2CHRM4CHRM5 | |
| SCHEMBL5232218 | 0.74 | ACHE (0.52) | MAOBHTR1ADRD2CHRM2CHRM4 | |
| SCHEMBL14028451 | 0.73 | HTR1A (0.79) | MAOBHTR1ADRD2DRD3 | |
| SCHEMBL13469510 | 0.73 | HTR1A (0.79) | MAOBHTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130030007-A1 | Obesity Small Molecules | AKRON MOLECULES GMBH (AT) | 2013-01-31 | — | — | US | disclosed |
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |