Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.48 |
| ▸ | RXRB | P28702 | 10/20 | 0.48 |
| ▸ | RXRG | P48443 | 10/20 | 0.48 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RNF4 | P78317 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 2/20 | 0.41 |
| ▸ | RARG | P13631 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556502 | 0.84 | RXRA (0.48) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL8555859 | 0.82 | RXRA (0.44) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL8675649 | 0.77 | RXRA (0.62) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL8556010 | 0.76 | RXRA (0.49) | RXRARXRBRXRGCYP26B1RARB | |
| SCHEMBL3934121 | 0.76 | RARB (0.58) | RXRARXRBRXRGCYP26B1NPC1 | |
| SCHEMBL8556269 | 0.76 | CYP26B1 (0.46) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL9471518 | 0.76 | NPC1 (0.69) | NPC1ALDH1A1HTTRAB9APAX8 | |
| SCHEMBL8560346 | 0.75 | RXRA (0.46) | RXRARXRBRXRGCYP26B1CYP26A1 | |
| SCHEMBL8093051 | 0.75 | RXRA (0.64) | RXRARXRBRXRGCYP26A1RARB | |
| SCHEMBL8102771 | 0.74 | ALDH1A1 (0.51) | RXRARXRBRXRGCYP26B1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | claimed |
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |