Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2747443 | 0.81 | HSD11B1 (0.57) | HSD11B1MEN1KMT2ABRD4 | |
| SCHEMBL8103086 | 0.80 | HSD11B1 (0.62) | HSD11B1CYP2C9 | |
| SCHEMBL8105700 | 0.75 | SLC6A3 (0.40) | — | |
| SCHEMBL28814864 | 0.74 | HSD11B1 (0.31) | HSD11B1MEN1KMT2ABRD4 | |
| SCHEMBL13430240 | 0.69 | HSD11B1 (0.30) | HSD11B1 | |
| SCHEMBL17317456 | 0.69 | HSD11B1 (0.51) | HSD11B1CYP2C9MEN1KMT2A | |
| SCHEMBL19618076 | 0.68 | CYP2C9 (0.41) | HSD11B1CYP2C9 | |
| SCHEMBL13430227 | 0.68 | HMGCR (0.35) | — | |
| SCHEMBL546128 | 0.67 | CYP2C9 (0.61) | CYP2C9 | |
| SCHEMBL23567008 | 0.67 | CHRNB2 (0.48) | MEN1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661271-B1 | AZEPINE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS SIGMA-RECEPTOR LIGANDS | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| US-5658923-A | USED IN TREATING DISEASES RELATED TO SIGMA-RECEPTOR, SUCH AS SCHIZOPHRENIA | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-08-19 | — | — | US | disclosed |
| EP-0661271-A1 | AZEPINE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-07-05 | — | — | EP | disclosed |