Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101368 | 0.72 | TRIM24 (0.39) | KDM4EALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL8109287 | 0.71 | KMT2A (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2AMYC | |
| SCHEMBL8103219 | 0.71 | ADORA3 (0.39) | SMN1; SMN2LMNAGAAMEN1KMT2A | |
| SCHEMBL8093553 | 0.70 | ADORA3 (0.31) | KMT2A | |
| SCHEMBL8101449 | 0.69 | MYC (0.40) | SMN1; SMN2LMNAGAAMEN1KMT2A | |
| SCHEMBL8093555 | 0.69 | GRM5 (0.33) | — | |
| SCHEMBL8109284 | 0.68 | GAA (0.37) | KDM4EALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL8101364 | 0.66 | KDM4E (0.40) | KDM4ESMN1; SMN2GAAHTTMAPT | |
| SCHEMBL8093773 | 0.66 | CHRM2 (0.33) | KDM4E | |
| SCHEMBL13922214 | 0.66 | GAA (0.51) | KDM4EALDH1A1SMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |