Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101449 | 0.93 | MYC (0.40) | ADORA3ADORA2AADORA1MAOALMNA | |
| SCHEMBL7468232 | 0.84 | ADRA2A (0.33) | ADORA3ADORA2AADORA1LMNASMN1; SMN2 | |
| SCHEMBL8107560 | 0.80 | PTGER4 (0.36) | KMT2AMEN1BRD4 | |
| SCHEMBL22883432 | 0.80 | MYC (0.34) | ADORA3ADORA2AADORA1MAOALMNA | |
| SCHEMBL8093553 | 0.78 | ADORA3 (0.31) | ADORA3ADORA2AADORA1KMT2ABRD4 | |
| SCHEMBL8103439 | 0.78 | KDM4E (0.40) | LMNASMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL8101368 | 0.77 | TRIM24 (0.39) | ADORA3ADORA2AADORA1LMNASMN1; SMN2 | |
| SCHEMBL8093555 | 0.77 | GRM5 (0.33) | ADORA3ADORA2AADORA1 | |
| SCHEMBL8103434 | 0.77 | ADRA2A (0.34) | ADORA3ADORA2AADORA1LMNASMN1; SMN2 | |
| SCHEMBL8107564 | 0.77 | ADRA2A (0.47) | LMNAKMT2AMEN1ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |