SCHEMBL8103389

SCHEMBL8103389

CC(=O)OC[C@H]1O[C@@H](n2cc(C)c(N)nc2=O)[C@@](O)(C(C)=O)[C@@]1(O)C(C)=O

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
POLA1 P09884 1/20 0.30
EP300 Q09472 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6223330 0.82 POLA1 (0.46) POLA1
SCHEMBL8924897 0.79 ALDH1A1 (0.42)
SCHEMBL6221793 0.78 LMNA (0.35) POLA1
SCHEMBL9556445 0.73 POLA1 (0.44) POLA1
SCHEMBL6222357 0.73 ADORA2A (0.50)
SCHEMBL6221779 0.73 HINT1 (0.49)
SCHEMBL2583271 0.72 LMNA (0.52)
SCHEMBL31685675 0.72 LMNA (0.52)
SCHEMBL9856461 0.72 LMNA (0.52)
SCHEMBL6223973 0.71 PDE4D (0.36) POLA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127152-A CONTACTING 2',3',5'-O-TRIACYLRIBONUCLEOSIDE DERIVATIVE WITH AN ESTER HYDROLASE OF A SPECIFIC AMINO ACID SEQUENCE TO REGIO-SELECTIVELY DEACYLATE THE ACYL GROUP AT THE 5'-O-POSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-10-03 US disclosed