Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.39 |
| ▸ | CES1 | P23141 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27964790 | 0.84 | CES2 (0.45) | CES2CES1ALDH1A1ALOX15HPGD | |
| SCHEMBL9844447 | 0.83 | TSHR (0.47) | CES2CES1ALDH1A1TSHRCYP3A4 | |
| SCHEMBL8574493 | 0.81 | PARP1 (0.43) | CES2CES1ALDH1A1HPGDCASP1 | |
| SCHEMBL10437029 | 0.81 | CES2 (0.38) | CES2CES1HPGDTSHRP2RX7 | |
| SCHEMBL27835380 | 0.79 | CES2 (0.36) | CES2CES1ALDH1A1ALOX15HPGD | |
| SCHEMBL27259216 | 0.79 | CES2 (0.36) | CES2CES1ALDH1A1ALOX15 | |
| SCHEMBL1311328 | 0.77 | ALDH1A1 (0.50) | ALDH1A1HPGDTSHRHSD17B10CYP3A4 | |
| SCHEMBL28267152 | 0.76 | ALOX15 (0.36) | CES2CES1ALDH1A1ALOX15HPGD | |
| SCHEMBL11726912 | 0.76 | TTR (0.37) | ALDH1A1ALOX15HPGDTSHRHSD17B10 | |
| SCHEMBL4514781 | 0.75 | ALDH1A1 (0.52) | CES2CES1ALDH1A1ALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104725221-B | The synthetic method of the chloro-5-fluorobenzoyl chloride of a kind of 2,4-bis- | ZHEJIANG BENLI CHEMICAL CO., LTD. (CN) | 2016-04-27 | — | — | CN | claimed |
| CN-104211590-B | The preparation method of the chloro-5-fluorobenzoyl chloride of a kind of 2,4-bis- | ZHEJIANG XIANFENG SCIENCE TECHNOLOGY Co.,Ltd. (CN) | 2016-01-20 | — | — | CN | claimed |
| CN-105175245-A | Synthesis method of 2,4-dichloro-5-fluorobenzoyl chloride | SHANDONG GUOBANG PHARMACEUTICAL CO LTD | 2015-12-23 | — | — | CN | claimed |
| CN-104725221-A | Method for synthesizing 2,4-dichloro-5-fluorobenzoyl | ZHEJIANG BENLI CHEMICAL CO LTD | 2015-06-24 | — | — | CN | claimed |
| EP-0306804-A2 | Process for the preparation of substituted benzyl trichlorides | BAYER AG (DE) | 1989-03-15 | — | — | EP | claimed |
| CN-104725221-B | The synthetic method of the chloro-5-fluorobenzoyl chloride of a kind of 2,4-bis- | ZHEJIANG BENLI CHEMICAL CO., LTD. (CN) | 2016-04-27 | — | — | CN | disclosed |
| CN-104725221-A | Method for synthesizing 2,4-dichloro-5-fluorobenzoyl | ZHEJIANG BENLI CHEMICAL CO LTD | 2015-06-24 | — | — | CN | disclosed |
| EP-0973936-A1 | COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS | ELI LILLY AND COMPANY (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998046786-A1 | COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS | ELI LILLY AND COMPANY (US) | 1998-10-22 | — | — | WO | disclosed |
| WO-1998008839-A1 | COMBINATORIAL PROCESS FOR PREPARING SUBSTITUTED THIOPHENE LIBRARIES | ELI LILLY AND COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |
| EP-0354444-A2 | Process for the introduction of fluorine on aromatic nucleus by nucleophilic exchange | BAYER AG (DE) | 1990-02-14 | — | — | EP | disclosed |