Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103503 | 0.83 | CES2 (0.39) | TSHRKEAP1CYP3A4ALDH1A1CASP1 | |
| SCHEMBL27964513 | 0.83 | KEAP1 (0.44) | TSHRKEAP1NFE2L2ALDH1A1TP53 | |
| SCHEMBL8574493 | 0.81 | PARP1 (0.43) | ALDH1A1CASP1CES2CES1CA1 | |
| SCHEMBL10437029 | 0.81 | CES2 (0.38) | TSHRSMN1; SMN2CES2CES1CLCN2 | |
| SCHEMBL6241684 | 0.81 | AKR1C2 (0.64) | KEAP1NFE2L2ALDH1A1TP53AKR1C4 | |
| SCHEMBL21250750 | 0.80 | NOTUM (0.40) | TSHRKEAP1CYP3A4NFE2L2ALDH1A1 | |
| SCHEMBL24898803 | 0.79 | KEAP1 (0.41) | TSHRKEAP1CYP3A4NFE2L2ALDH1A1 | |
| SCHEMBL27980487 | 0.79 | ALDH1A1 (0.44) | TSHRKEAP1CYP3A4NFE2L2ALDH1A1 | |
| SCHEMBL2062742 | 0.79 | KEAP1 (0.50) | TSHRKEAP1CYP3A4NFE2L2ALDH1A1 | |
| SCHEMBL31055678 | 0.79 | KEAP1 (0.41) | TSHRKEAP1CYP3A4NFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190307766-A1 | CYCLIC AMINES | MINDIMMUNE THERAPEUTICS, INC. | 2019-10-10 | — | — | US | disclosed |
| EP-3536689-A1 | 2-(CYCLIC AMINEETHYL)BENZAMIDE DERIVATIVES AS P2X7 INHIBITORS | MindImmune Therapeutics, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |
| EP-2906549-B1 | N-(2-(CYCLIC AMINE)ETHYL)BENZAMIDE DERIVATIVES AS P2X7 INHIBITORS | MINDIMMUNE THERAPEUTICS INC (US) | 2019-04-17 | — | — | EP | disclosed |
| US-10124010-B2 | Cyclic amines | MINDIMMUNE THERAPEUTICS, INC. (US) | 2018-11-13 | — | — | US | disclosed |
| US-20180177793-A1 | CYCLIC AMINES | MINDIMMUNE THERAPEUTICS, INC. | 2018-06-28 | — | — | US | disclosed |
| US-9861639-B2 | Cyclic amines | H. LUNDBECK A/S (DK) | 2018-01-09 | — | — | US | disclosed |
| US-20170128460-A1 | Cyclic Amines | H. LUNDBECK A/S (DK) | 2017-05-11 | — | — | US | disclosed |
| US-9593105-B2 | Cyclic amines | H. LUNDBECK A/S (DK) | 2017-03-14 | — | — | US | disclosed |
| US-20170008898-A1 | Cyclic Amines | H. LUNDBECK A/S (DK) | 2017-01-12 | — | — | US | disclosed |
| US-9415055-B2 | Cyclic amines | H. LUNDBECK A/S (DK) | 2016-08-16 | — | — | US | disclosed |
| US-20150306114-A1 | Cyclic Amines | MINDIMMUNE THERAPEUTICS, INC. | 2015-10-29 | — | — | US | disclosed |
| EP-2906549-A2 | CYCLIC AMINES | H. Lundbeck A/S (DK) | 2015-08-19 | — | — | EP | disclosed |
| US-9108938-B2 | Cyclic amines | H. LUNDBECK A/S (DK) | 2015-08-18 | — | — | US | disclosed |
| US-20140107335-A1 | Cyclic Amines | H. LUNDBECK A/S (DK) | 2014-04-17 | — | — | US | disclosed |
| WO-2014057080-A2 | CYCLIC AMINES | H. LUNDBECK A/S (DK) | 2014-04-17 | — | — | WO | disclosed |
| EP-0431373-A2 | Processes for producing 5-fluorbenzoic acids and their intermediates | ASAHI GLASS COMPANY LTD. (JP) | 1991-06-12 | — | — | EP | disclosed |
| EP-0303291-A2 | Fluorinated benzoyl compounds | ASAHI GLASS COMPANY LTD. (JP) | 1989-02-15 | — | — | EP | disclosed |
| EP-0274033-A1 | Process for the preparation of quinolinecarboxylic acids | BAYER AG (DE) | 1988-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008898-A1 | Cyclic Amines | P2RX7, ADORA2A, P2RX2 | TSHR 664/4885KEAP1 1572/4885CYP3A4 1619/4885 |
| US-20150306114-A1 | Cyclic Amines | P2RX7, ADORA2A, P2RX2 | TSHR 664/4885KEAP1 1572/4885CYP3A4 1619/4885 |
| US-20190307766-A1 | CYCLIC AMINES | P2RX7, ADORA2A, P2RX2 | TSHR 664/4885KEAP1 1572/4885CYP3A4 1619/4885 |
| US-20140107335-A1 | Cyclic Amines | P2RX7, ADORA2A, P2RX2 | TSHR 664/4885KEAP1 1572/4885CYP3A4 1619/4885 |
| US-10124010-B2 | Cyclic amines | P2RX7, ADORA2A, P2RX2 | TSHR 664/4885KEAP1 1572/4885CYP3A4 1619/4885 |
| US-20180177793-A1 | CYCLIC AMINES | P2RX7, ADORA2A, P2RX2 | TSHR 664/4885KEAP1 1572/4885CYP3A4 1619/4885 |
| US-20170128460-A1 | Cyclic Amines | P2RX7, ADORA2A, P2RX2 | TSHR 664/4885KEAP1 1572/4885CYP3A4 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.