Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.59 |
| ▸ | PLK1 | P53350 | 2/20 | 0.59 |
| ▸ | THRB | P10828 | 6/20 | 0.57 |
| ▸ | THRA | P10827 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020423 | 0.96 | RARB (0.62) | RARBPLK1THRBTHRAALDH1A1 | |
| SCHEMBL1019681 | 0.92 | PLK1 (0.60) | RARBPLK1THRBTHRAALDH1A1 | |
| SCHEMBL12656104 | 0.91 | RARB (0.72) | RARBPLK1THRBTHRAALDH1A1 | |
| SCHEMBL158152 | 0.91 | THRA (0.67) | RARBTHRBTHRAALDH1A1MEN1 | |
| SCHEMBL7728431 | 0.91 | THRA (0.59) | RARBTHRBTHRAALDH1A1MEN1 | |
| SCHEMBL1020543 | 0.89 | THRA (0.70) | RARBTHRBTHRAALDH1A1MEN1 | |
| SCHEMBL8960387 | 0.89 | THRA (0.70) | RARBTHRBTHRAALDH1A1MEN1 | |
| SCHEMBL17272985 | 0.89 | THRA (0.70) | RARBTHRBTHRAALDH1A1MEN1 | |
| SCHEMBL8728345 | 0.89 | THRA (0.70) | RARBTHRBTHRAALDH1A1MEN1 | |
| SCHEMBL2180222 | 0.89 | THRA (0.70) | RARBTHRBTHRAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973936-A1 | COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS | ELI LILLY AND COMPANY (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998046786-A1 | COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS | ELI LILLY AND COMPANY (US) | 1998-10-22 | — | — | WO | disclosed |