SCHEMBL1020423

SCHEMBL1020423

CCCCc1ccc(C(=O)Cl)cc1

nearest known ligand 0.62

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
RARB P10826 6/20 0.62
PLK1 P53350 1/20 0.62
THRA P10827 7/20 0.61
THRB P10828 7/20 0.61
ALDH1A1 P00352 3/20 0.58
HPGD P15428 1/20 0.58
HSD17B10 Q99714 1/20 0.58
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
RARA P10276 1/20 0.54
MAPT P10636 1/20 0.54
MTOR P42345 1/20 0.54
TRPV1 Q8NER1 1/20 0.54
PLA2G1B P04054 1/20 0.51
ATG4B Q9Y4P1 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8103655 0.96 RARB (0.59) RARBPLK1THRATHRBALDH1A1
SCHEMBL12656104 0.94 RARB (0.72) RARBPLK1THRATHRBALDH1A1
SCHEMBL158152 0.94 THRA (0.67) RARBTHRATHRBALDH1A1MEN1
SCHEMBL8728345 0.92 THRA (0.70) RARBTHRATHRBALDH1A1MEN1
SCHEMBL1021352 0.92 THRA (0.70) RARBTHRATHRBALDH1A1MEN1
SCHEMBL9431010 0.92 THRA (0.70) RARBTHRATHRBALDH1A1MEN1
SCHEMBL269399 0.92 THRA (0.70) RARBTHRATHRBALDH1A1MEN1
SCHEMBL8960387 0.92 THRA (0.70) RARBTHRATHRBALDH1A1MEN1
SCHEMBL17272985 0.92 THRA (0.70) RARBTHRATHRBALDH1A1MEN1
SCHEMBL1020543 0.92 THRA (0.70) RARBTHRATHRBALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 492 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118955940-A Agricultural and forestry waste-based thermoplastic plastic and preparation method thereof 西南林业大学 2024-11-15 CN claimed
CN-114853627-B Substituted docosahexaenoic amide ethyl benzoate derivative and preparation method and application thereof 自然资源部第三海洋研究所 2023-06-20 CN claimed
CN-114853627-A Substituted docosahexaenoic acid diethyl ester derivative as well as preparation method and application thereof 自然资源部第三海洋研究所 2022-08-05 CN claimed
CN-109574842-B Vegetable oil polyalcohol and preparation method and application thereof 南京工业大学 2020-05-05 CN claimed
CN-108299150-A The synthetic method of 4- n-butylbenzene formyl chlorides 江苏佳麦化工有限公司 2018-07-20 CN claimed
US-6214990-B1 2,9-BIS(4-METHOXYBENZOYLOXY),3,10-DIMETHOXY,6,13-DICHLORO -PHENODIOXAZINE, FOR EXAMPLE; DYE HAS NARROW LIGHT ABORPTION BAND AND HIGH DICHROIC RATIO SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-04-10 US claimed
EP-0440329-A1 S-substituted carbonyl substituted betathioacrylamide biocides and fungicides ROHM AND HAAS COMPANY (US) 1991-08-07 EP claimed
US-20250248990-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE NEURODON CORPORATION 2025-08-07 US disclosed
US-20250250249-A1 NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS NATIONAL YANG MING CHIAO TUNG UNIVERSITY (TW) 2025-08-07 US disclosed
US-12312326-B2 Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors Tseng, Yufeng Jane (US) 2025-05-27 US disclosed
WO-2024235876-A1 PYRIDOPYRIMIDINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS FERNANDEZ CAPETILLO OSCAR (SE) 2024-11-21 WO disclosed
US-12144806-B2 Quinolines that modulate SERCA and their use for treating disease NEURODON CORPORATION (US) 2024-11-19 US disclosed
CN-118955940-A Agricultural and forestry waste-based thermoplastic plastic and preparation method thereof 西南林业大学 2024-11-15 CN disclosed
US-4284813-A Benzamide derivatives and herbicidal composition containing the same HODOGAYA CHEMICAL CO., LTD. (JP) 1981-08-18 US disclosed
US-4200580-A Dioxanylphenyl benzoate liquid crystal compounds TIMEX CORPORATION (US) 1980-04-29 US disclosed
US-4167489-A AN IMINE-ESTER AROMATIC COMPOUND BBC BROWN BOVERI & COMPANY, LIMITED (CH) 1979-09-11 US disclosed
US-4136053-A BIPHENYL ESTERS AND LIQUID CRYSTALLINE MIXTURES COMPRISING THEM MERCK PATENT GESELLSCHAFT MIT BESCHANKTER HAFTUNG (DE) 1979-01-23 US disclosed
US-4065489-A Biphenyl esters and liquid crystalline mixtures comprising them MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1977-12-27 US disclosed
US-4058478-A P-ALKYLBENZOIC ACID P'-CYANOPHENYL ESTER HOFFMANN-LA ROCHE INC. (US) 1977-11-15 US disclosed
US-3963311-A Liquid crystal esters HOFFMANN-LA ROCHE INC. (US) 1976-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250250249-A1 NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS D-AMINO ACID OXIDASE (DAAO) INHIBITORS DAO, DDO, DDC RARB 1403/4885PLK1 4346/4885THRA 3513/4885
US-12144806-B2 Quinolines that modulate SERCA and their use for treating disease ATP2A1, ATP2A3, ATP2A2 RARB 3368/4885PLK1 3535/4885THRA 2810/4885
US-20250248990-A1 QUINOLINES THAT MODULATE SERCA AND THEIR USE FOR TREATING DISEASE ATP2A1, ATP2A3, ATP2A2 RARB 3368/4885PLK1 3535/4885THRA 2810/4885
US-12312326-B2 Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors DAO, DDO, DDC RARB 1716/4885PLK1 4254/4885THRA 3862/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.