Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157376 | 0.80 | ALDH1A1 (0.64) | ALDH1A1CYP3A4KMT2APOLBMAPT | |
| SCHEMBL712324 | 0.78 | KMT2A (0.56) | ALDH1A1CYP3A4KMT2AMEN1LMNA | |
| SCHEMBL710572 | 0.77 | CYP2D6 (0.46) | ALDH1A1CYP3A4KMT2ALMNATDP1 | |
| SCHEMBL8886285 | 0.77 | L3MBTL1 (0.50) | ALDH1A1CYP3A4KMT2ALMNATDP1 | |
| SCHEMBL1371273 | 0.75 | MMP8 (0.50) | ALDH1A1CYP3A4KMT2AMAPTMEN1 | |
| SCHEMBL1680117 | 0.74 | ALDH1A1 (0.41) | ALDH1A1CYP3A4KMT2APOLBMAPT | |
| SCHEMBL212215 | 0.74 | ALDH1A1 (0.51) | ALDH1A1KMT2ALMNATDP1L3MBTL1 | |
| SCHEMBL9068581 | 0.74 | ALDH1A1 (0.51) | ALDH1A1CYP3A4KMT2ALMNATSHR | |
| SCHEMBL28420265 | 0.74 | LMNA (0.57) | ALDH1A1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL9793557 | 0.73 | KMT2A (0.46) | ALDH1A1CYP3A4KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150511-B2 | Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof | APICORE US LLC (US) | 2015-10-06 | — | — | US | disclosed |
| US-20140235870-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | APICORE, LLC (US) | 2014-08-21 | — | — | US | disclosed |
| WO-2012162507-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | APICORE, LLC (US) | 2012-11-29 | — | — | WO | disclosed |
| US-6121442-A | 1,2-dialkinylated compounds | UNIVERSITY OF HEILDELBERG (DE) | 2000-09-19 | — | — | US | disclosed |
| WO-1998000386-A1 | 1,2-DIALKINYLATED COMPOUNDS | Universität Heidelberg (DE) | 1998-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235870-A1 | PROCESS FOR PREPARING SAXAGLIPTIN AND ITS NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | DPP4, DPP3, DPP8 | ALDH1A1 1533/4885CYP3A4 38/4885KMT2A 3906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.