Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 3/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 4/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099954 | 0.89 | ABL1 (0.40) | ABL1PIK3R1PIK3CASMN1; SMN2RORC | |
| SCHEMBL8083973 | 0.88 | ALDH1A1 (0.43) | PIK3R1PIK3CANPC1RAB9AALDH1A1 | |
| SCHEMBL8083683 | 0.81 | NPC1 (0.42) | PIK3R1PIK3CANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8089917 | 0.81 | PIK3CA (0.39) | PIK3CAALDH1A1CA2CA9NAMPT | |
| SCHEMBL8092637 | 0.81 | KMT2A (0.42) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL3926957 | 0.80 | PIK3CA (0.47) | PIK3R1PIK3CA | |
| SCHEMBL8083334 | 0.80 | CA1 (0.41) | PIK3R1PIK3CAALDH1A1CA12CA1 | |
| SCHEMBL8097257 | 0.80 | ALDH1A1 (0.41) | PIK3CARAB9AALDH1A1CA12CA1 | |
| SCHEMBL8094619 | 0.80 | PIP4K2A (0.40) | PIK3R1PIK3CANAMPT | |
| SCHEMBL8083200 | 0.79 | ALDH1A1 (0.43) | PIK3R1PIK3CAALDH1A1TDO2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |