Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104112 | 0.67 | KMT2A (0.35) | KDM4ENPSR1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL8094793 | 0.67 | L3MBTL1 (0.37) | ALDH1A1POLBL3MBTL1SMN1; SMN2APEX1 | |
| SCHEMBL8102580 | 0.66 | KMT2A (0.40) | ALDH1A1KMT2A | |
| SCHEMBL8441250 | 0.63 | ACE (0.37) | KDM4ENPSR1ALDH1A1ACE | |
| SCHEMBL5547511 | 0.62 | ACE (0.31) | KDM4ELMNAACE | |
| SCHEMBL18106803 | 0.62 | L3MBTL1 (0.43) | KDM4ENPSR1LMNAALDH1A1POLB | |
| SCHEMBL8772453 | 0.60 | ACE (0.37) | KDM4ENPSR1ACE | |
| SCHEMBL28923751 | 0.58 | BRD4 (0.43) | KDM4ENPSR1LMNAALDH1A1MAPT | |
| SCHEMBL515800 | 0.57 | PTGS1 (0.52) | KDM4ENPSR1LMNAALDH1A1MAPT | |
| SCHEMBL783054 | 0.57 | CHRM2 (0.46) | POLBTSHRACEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | disclosed |