Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623237 | 0.77 | ALDH1A1 (0.42) | NOTUMIDO1DCUN1D1NISCHALDH1A1 | |
| SCHEMBL9903469 | 0.77 | NOTUM (0.46) | NOTUM | |
| SCHEMBL7853517 | 0.70 | NOTUM (0.45) | NOTUMIDO1 | |
| SCHEMBL4630228 | 0.70 | IDO1 (0.33) | IDO1ALDH1A1NPC1L3MBTL1KDM4E | |
| SCHEMBL28018833 | 0.65 | KDM4E (0.39) | NOTUMIDO1DCUN1D1NISCHALDH1A1 | |
| SCHEMBL29547174 | 0.65 | ACHE (0.47) | NOTUMIDO1DCUN1D1NISCHALDH1A1 | |
| SCHEMBL197834 | 0.65 | ACHE (0.47) | NOTUMIDO1DCUN1D1NISCHALDH1A1 | |
| SCHEMBL8117022 | 0.65 | NFE2L2 (0.53) | NPC1PKMRAB9AL3MBTL1KDM4E | |
| SCHEMBL30497931 | 0.64 | IDO1 (0.53) | NOTUMIDO1DCUN1D1NISCHALDH1A1 | |
| SCHEMBL2277157 | 0.64 | IDO1 (0.53) | NOTUMIDO1DCUN1D1NISCHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000055-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. Searle & Co. (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1998052940-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE AND CO. (US) | 1998-11-26 | — | — | WO | disclosed |