⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19099432 | 0.92 | ALDH1A1 (0.48) | — | |
| SCHEMBL3411276 | 0.73 | MAOA (0.64) | — | |
| SCHEMBL4123832 | 0.73 | MAOA (0.64) | — | |
| SCHEMBL224947 | 0.73 | CYP2A6 (0.57) | — | |
| SCHEMBL6363151 | 0.71 | — | — | |
| Water SCHEMBL28293836 | 0.71 | CYP2A6 (0.53) | — | |
| SCHEMBL18508 | 0.71 | — | — | |
| SCHEMBL23657328 | 0.70 | MAPT (0.38) | — | |
| SCHEMBL381447 | 0.69 | ALDH1A1 (0.58) | — | |
| SCHEMBL7938361 | 0.69 | NR1H2 (0.74) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108601788-A | EIF 4A-inhibiting compounds and methods relating thereto | 效应治疗股份有限公司 | 2018-09-28 | — | — | CN | disclosed |
| EP-2345652-A1 | Antiviral compounds | Abbott Laboratories (US) | 2011-07-20 | — | — | EP | disclosed |
| US-7915411-B2 | Anti-viral compounds | ABBOTT LABORATORIES (US) | 2011-03-29 | — | — | US | disclosed |
| US-7872134-B2 | 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates | TELIK, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| US-7655799-B2 | 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates | TELIK, INC. (US) | 2010-02-02 | — | — | US | disclosed |
| EP-2097139-A1 | 2-{[2-(SUBSTITUTED AMINO)ETHYL]SULFONYL}ETHYL N,N,N',N'-TETRAKIS(2 -CHLOROETHYL)PHOSPHORODIAMIDATES | TELIK, INC. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009076473-A1 | 2-{[2-(SUBSTITUTED AMINO)ETHYL]SULFONYL}ETHYL N,N-BIS(2- CHLOROETHYL)PHOSPHORODIAMIDATES | TELIK, INC. (US) | 2009-06-18 | — | — | WO | disclosed |
| US-20090156559-A1 | 2-ethyl N,N-bis(2-chloroethyl)phosphorodiamidates | TELIK, INC. | 2009-06-18 | — | — | US | disclosed |
| EP-1971611-A1 | ANTI-VIRAL COMPOUNDS | Abbott Laboratories (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2008066515-A1 | 2-({2-OXO-2-[(PYRIDIN-3-YLMETHYL)AMINO]ETHYL}SULFONYL)ETHYL N,N,N',N'-TETRAKIS(2-CHLOROETHYL)PHOSPHORODIAMIDATE | TELIK, INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008066526-A1 | 2-{[2-(SUBSTITUTED AMINO)ETHYL]SULFONYL}ETHYL N,N,N',N'-TETRAKIS(2 -CHLOROETHYL)PHOSPHORODIAMIDATES | TELIK, INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| US-20080125398-A1 | 2-ETHYL N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates | TELIK, INC. | 2008-05-29 | — | — | US | disclosed |
| US-20080125397-A1 | 2 (SULFONYL)ETHYL N,N,N',N' tetrakis(2 chloroethyl)phosphorodia | TELIK, INC. | 2008-05-29 | — | — | US | disclosed |
| US-20070197558-A1 | ANTI-VIRAL COMPOUNDS | ABBVIE INC. | 2007-08-23 | — | — | US | disclosed |
| WO-2007081517-A2 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2007-07-19 | — | — | WO | disclosed |