Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | EIF2S1 | P05198 | 1/20 | 0.37 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092850 | 0.92 | CA12 (0.42) | CA12CA1CA2CA9GHSR | |
| SCHEMBL8097581 | 0.91 | MAPT (0.38) | CA12CA1CA2CA9MAPT | |
| SCHEMBL8098658 | 0.90 | MAPT (0.37) | CA12CA1CA2CA9MAPT | |
| SCHEMBL8098657 | 0.90 | MAPT (0.37) | CA12CA1CA2CA9MAPT | |
| SCHEMBL8090246 | 0.90 | PIK3CA (0.42) | MAPTKDM4EHTTNAMPTMEN1 | |
| SCHEMBL8104053 | 0.89 | CA2 (0.41) | CA12CA1CA2CA9GHSR | |
| SCHEMBL8096342 | 0.88 | PIK3CA (0.41) | MAPTKDM4EHTTNAMPTMEN1 | |
| SCHEMBL8092294 | 0.88 | ROCK2 (0.39) | CA12CA1CA2CA9GHSR | |
| SCHEMBL8098188 | 0.88 | CA12 (0.44) | CA12CA1CA2CA9MAPT | |
| SCHEMBL8089531 | 0.87 | CA12 (0.43) | CA12CA1CA2CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |