Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.95 |
| ▸ | MAPT | P10636 | 6/20 | 0.95 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.95 |
| ▸ | HTT | P42858 | 5/20 | 0.82 |
| ▸ | HPGD | P15428 | 4/20 | 0.82 |
| ▸ | TP53 | P04637 | 3/20 | 0.82 |
| ▸ | MAOB | P27338 | 2/20 | 0.82 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 5/20 | 0.73 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29386543 | 1.00 | ALDH1A1 (0.95) | ALDH1A1MAPTHSD17B10HTTHPGD | |
| SCHEMBL668026 | 0.99 | ALDH1A1 (0.97) | ALDH1A1MAPTHSD17B10HTTHPGD | |
| SCHEMBL15563003 | 0.94 | ALDH1A1 (0.90) | ALDH1A1MAPTHSD17B10HTTHPGD | |
| SCHEMBL12123672 | 0.90 | ALDH1A1 (1.00) | ALDH1A1MAPTHSD17B10HTTHPGD | |
| SCHEMBL14578168 | 0.83 | ACHE (0.72) | ALDH1A1MAPTHSD17B10HTTHPGD | |
| SCHEMBL12123816 | 0.83 | ALDH1A1 (0.87) | ALDH1A1MAPTHSD17B10HTTHPGD | |
| SCHEMBL653025 | 0.83 | PKM (0.87) | ALDH1A1HPGDPKMTSHRCTNNB1 | |
| SCHEMBL22651290 | 0.83 | ALDH1A1 (0.71) | ALDH1A1MAPTHSD17B10HTTHPGD | |
| SCHEMBL29773054 | 0.83 | ALDH1A1 (0.71) | ALDH1A1MAPTHSD17B10HTTHPGD | |
| SCHEMBL22638785 | 0.82 | ALDH1A1 (0.97) | ALDH1A1MAPTHSD17B10HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114072398-B | Compounds that inhibit TDG activity | 上海仕谱生物科技有限公司 | 2024-06-11 | — | — | CN | disclosed |
| US-20220213070-A1 | COMPOUNDS INHIBITING TDG ACTIVITY | Epitas Biosciences (shanghai) Co., Ltd. (CN) | 2022-07-07 | — | — | US | disclosed |
| US-20220213070-A1 | COMPOUNDS INHIBITING TDG ACTIVITY | Epitas Biosciences (shanghai) Co., Ltd. (CN) | 2022-07-07 | — | — | US | disclosed |
| EP-3971180-A1 | COMPOUNDS INHIBITING TDG ACTIVITY | Epitas Biosciences (Shanghai) Co., Ltd. (CN) | 2022-03-23 | — | — | EP | disclosed |
| CN-114072398-A | Compounds that inhibit TDG activity | 上海仕谱生物科技有限公司 | 2022-02-18 | — | — | CN | disclosed |
| WO-2020224396-A1 | COMPOUNDS INHIBITING TDG ACTIVITY | 上海仕谱生物科技有限公司 | 2020-11-12 | — | — | WO | disclosed |
| WO-2020224396-A1 | COMPOUNDS INHIBITING TDG ACTIVITY | 上海仕谱生物科技有限公司 | 2020-11-12 | — | — | WO | disclosed |
| CN-111909138-A | Compounds that inhibit TDG activity | 上海仕谱生物科技有限公司 | 2020-11-10 | — | — | CN | disclosed |
| WO-2015042397-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES | BIOMARIN PHARMACEUTICAL INC. (US) | 2015-03-26 | — | — | WO | disclosed |
| WO-2008150486-A2 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213070-A1 | COMPOUNDS INHIBITING TDG ACTIVITY | TDO2, TFPI, PPIG | ALDH1A1 1309/4885MAPT 3200/4885HSD17B10 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.