Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.47 |
| ▸ | WNT3A | P56704 | 3/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5159751 | 0.85 | CES2 (0.55) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL253276 | 0.85 | CES2 (0.64) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL29355245 | 0.85 | CES2 (0.64) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL5163181 | 0.82 | ALDH1A1 (0.53) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL33721999 | 0.81 | CES2 (0.59) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL2544523 | 0.81 | CES2 (0.59) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL28131851 | 0.81 | HDAC3 (0.61) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL109657 | 0.81 | HDAC3 (0.61) | CES2CES1LMNANAPRTP4HTM | |
| SCHEMBL9493294 | 0.79 | LMNA (0.61) | CES2CES1LMNANAPRTP4HTM | |
| Hydrochloric Acid SCHEMBL17500942 | 0.79 | HDAC3 (0.59) | CES2CES1LMNANAPRTP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0694545-B1 | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | SEARLE & CO (US) | 2000-07-26 | — | — | EP | disclosed |
| EP-0583421-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | G.D. SEARLE & CO. (US) | 1994-02-23 | — | — | EP | disclosed |