Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11628857 | 0.85 | ALDH1A1 (0.48) | PKMSMN1; SMN2MAOAMAOBCYP19A1 | |
| SCHEMBL5687905 | 0.84 | OPRM1 (0.49) | TDP1PKMSMN1; SMN2CASP1TRPV1 | |
| SCHEMBL250955 | 0.82 | TDP1 (0.68) | TDP1PKMSMN1; SMN2CASP1ALDH1A1 | |
| SCHEMBL1068218 | 0.81 | CYP4F2 (0.55) | TDP1SMN1; SMN2MAOAMAOBCYP19A1 | |
| SCHEMBL8104566 | 0.81 | FAAH (0.41) | TDP1PKMSMN1; SMN2CASP1MAOA | |
| SCHEMBL6999007 | 0.80 | CASP1 (0.46) | CASP1MAOAMAOBCYP19A1TSHR | |
| SCHEMBL5450328 | 0.79 | TDP1 (0.56) | TDP1CASP1MAOAMAOBCYP19A1 | |
| Hydrochloric Acid SCHEMBL3021844 | 0.79 | CYP4F2 (0.54) | TDP1SMN1; SMN2MAOAMAOBCYP19A1 | |
| SCHEMBL7781858 | 0.79 | APP (0.51) | TDP1PKMSMN1; SMN2CASP1CYP19A1 | |
| SCHEMBL16016129 | 0.79 | MAOB (0.52) | TDP1SMN1; SMN2MAOAMAOBCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590885-B1 | Antibiotic carbapenem compounds | ZENECA LTD (GB) | 2000-03-15 | — | — | EP | disclosed |
| US-5527791-A | Carbapenem antibiotic compounds | ZENECA LIMITED (GB) | 1996-06-18 | — | — | US | disclosed |
| EP-0590885-A1 | Antibiotic carbapenem compounds | ZENECA LIMITED (GB) | 1994-04-06 | — | — | EP | disclosed |
| EP-0077662-B1 | PREPARATION OF NITROARYLACETIC ACID ESTERS AND DERIVATIVES THEREOF | ETHYL CORPORATION (US) | 1985-10-02 | — | — | EP | disclosed |