SCHEMBL8115604

SCHEMBL8115604

CC(=O)Nc1ccc(-c2ccncc2)c(Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.51
KDM4E B2RXH2 2/20 0.51
GAA P10253 2/20 0.51
HPGD P15428 1/20 0.51
LMNA P02545 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
POLB P06746 2/20 0.50
MAPK1 P28482 1/20 0.50
TSHR P16473 1/20 0.49
RORC P51449 3/20 0.48
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
MAPT P10636 2/20 0.48
NTRK1 P04629 1/20 0.46
DNMT1 P26358 1/20 0.46
HTT P42858 1/20 0.46
DUSP3 P51452 1/20 0.46
BLM P54132 1/20 0.46
CACNA1B Q00975 1/20 0.46
APBA1 Q02410 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8118565 0.86 JAK2 (0.44) ALDH1A1KDM4EGAAHPGDLMNA
SCHEMBL6287443 0.84 RORC (0.58) ALDH1A1HPGDSMN1; SMN2RORCMEN1
SCHEMBL8589404 0.82 GSTO1 (0.50) ALDH1A1KDM4EGAALMNASMN1; SMN2
SCHEMBL2184246 0.79 AAK1 (0.65) ALDH1A1KDM4EGAAHPGDPOLB
SCHEMBL8115699 0.78 S1PR1 (0.55) ALDH1A1KDM4EGAAHPGDTSHR
SCHEMBL3728246 0.77 SMN1; SMN2 (0.76) ALDH1A1KDM4EGAAHPGDSMN1; SMN2
SCHEMBL4548035 0.75 EPHX1 (0.70) KDM4EGAALMNASMN1; SMN2POLB
SCHEMBL8118567 0.74 MEN1 (0.50) ALDH1A1GAAHPGDLMNASMN1; SMN2
SCHEMBL6998722 0.74 ADORA2B (0.43) KDM4EPOLBTSHRMEN1KMT2A
SCHEMBL10663620 0.73 CYP17A1 (0.76) ALDH1A1SMN1; SMN2TSHRMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047691-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-11-02 EP disclosed
EP-0975593-A1 INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 2000-02-02 EP disclosed
WO-1999031086-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-06-24 WO disclosed
WO-1998050358-A1 INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1998-11-12 WO disclosed
WO-1998050346-A2 ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS SMITHKLINE BEECHAM PLC (GB) 1998-11-12 WO disclosed