Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 4/20 | 0.37 |
| ▸ | CCND1 | P24385 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10975857 | 0.82 | NOTUM (0.53) | SLC6A2NOTUMHTR2AHTR2CCDK4 | |
| SCHEMBL4102885 | 0.79 | SLC6A2 (0.49) | SLC6A2NOTUMHTR2AHTR2CMAPK1 | |
| SCHEMBL3365470 | 0.77 | SLC6A2 (0.58) | SLC6A2NOTUMHTR2AHTR2CCDK4 | |
| SCHEMBL8836092 | 0.73 | SLC6A2 (0.44) | SLC6A2NOTUMHTR2AHTR2CCDK4 | |
| SCHEMBL6006493 | 0.73 | SLC6A2 (0.50) | SLC6A2NOTUMHTR2AHTR2CCDK4 | |
| Hydrochloric Acid SCHEMBL8835946 | 0.72 | SLC6A2 (0.43) | SLC6A2NOTUMHTR2AHTR2CCDK4 | |
| SCHEMBL4108676 | 0.71 | L3MBTL1 (0.42) | SLC6A2NOTUMMAPK1ALDH1A1MAPT | |
| SCHEMBL6625810 | 0.70 | SLC6A2 (0.75) | SLC6A2NOTUMHTR2AHTR2CCDK4 | |
| SCHEMBL6005012 | 0.69 | SLC6A2 (0.50) | SLC6A2NOTUMHTR2AHTR2CCDK4 | |
| SCHEMBL8836095 | 0.67 | LMNA (0.49) | SLC6A2NOTUMHTR2AHTR2CCDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |